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Studies in healthy volunteers show that in single high doses Ativan (lorazepam) has a tranquilizing action on the CNS with no appreciable effect on the respiratory or cardiovascular systems.

Ativan is readily absorbed with an absolute bioavailability of 90 percent. Peak concentrations in plasma occur approximately 2 hours following the drug administration. The peak plasma level of Ativan from a 2 mg dose is approximately 20 ng/mL.

The mean half-life of unconjugated Ativan in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide, about 18 hours. At clinically relevant concentrations, this drug is approximately 85% bound to plasma proteins. Ativan is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. Ativan glucuronide has no demonstrable CNS activity in animals.

The plasma levels of Ativan are proportional to the dosage given. There is no evidence of accumulation of Ativan on administration up to six months.

Studies comparing young and elderly subjects have shown that advancing age does not have a significant effect on the pharmacokinetics of Ativan. However, in one study involving single intravenous doses of 1.5 to 3 mg of Ativan Injection, mean total body clearance of Ativan decreased by 20% in 15 elderly subjects of 60 to 84 years of age compared to that in 15 younger subjects of 19 to 38 years of age. Ativan is used for the treatment of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension related with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of Ativan in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The attending physician should periodically reassess the usefulness of the drug for the individual patient.